The cloning of GABA(sub B) receptors
Article Abstract:
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the brain that acts on two different types of target receptor, namely, GABA (sub A) and GABA(sub B). Although the GABA(sub A) has been cloned in the 1980s, it took a decade for the GABA(sub B) receptor to be cloned when two forms of rat GABA(sub B) receptor complementary deoxyribonucleic acid were cloned using a new high-affinity antagonist for the GABA(sub B) receptor. The GABA(sub B) receptor works to open adjacent potassium channels, close voltage-gated calcium channels, and inhibit the enzyme adenylyl cyclase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Endogenous neurosteroids regulate [GABA.sub.A] receptors through two discrete transmembrane sites
Article Abstract:
Two discrete binding sites are identified in the [GABA.sub.A] receptor's transmembrane domains that mediate the potentiating and direct activation effects of neurosteroids. The activation and potentiation sites are highly conserved throughout the [GABA.sub.A] receptor family and their identification has provided an opportunity for the development of new therapeutic, neurosteroid-based ligands and transgenic disease models of neurosteroid dysfunction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Reversal of pathological pain through specific spinal [GABA.sub.A] receptor subtypes
Article Abstract:
The role of the [gamma]-aminobutyric acid (GABA) receptors in achieving pronounced analgesia is discussed. Few of these receptors are found to be highly effective against the inflammatory and neuropathic pain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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